特色产品

AP5501 ecmbiosciences AIFM1 (Ser-116) 磷酸化抗体

Apoptosis-inducing factor (AIFM1, AIF, PDCD8) is a ubiquitously expressed flavoprotein that plays a critical role in caspase-independent apoptosis. AIFM1 is expressed as a 66 kDa precursor protein bef

  • 货号:

Apoptosis-inducing factor (AIFM1, AIF, PDCD8) is a ubiquitously expressed flavoprotein that plays a critical role in caspase-independent apoptosis. AIFM1 is expressed as a 66 kDa precursor protein before being N-terminally cleaved to 62 kDa and localized to the mitochondrial intermembrane space. In response to apoptotic stimuli, AIFM1 is released from the mitochondrial intermembrane as a 57 kDa fragment that can translocate to the nucleus. Treatment of isolated nuclei with recombinant AIFM1 leads to early apoptotic events, such as chromatin condensation and large-scale DNA fragmentation. Studies of AIFM1 knockout mice have shown that the apoptotic activity of AIFM1 is cell type and stimuli-dependent. AIFM1 has been implicated in oxeiptosis, a non-inflammatory, caspase independent cell death pathway caused by oxidative stress. During oxeiptosis, increased reactive oxygen species cause the release of the phosphatase PGAM5 from KEAP1 leading to dephosphorylation of AIFM1 (Ser-116) and subsequent cell death. Thus, AIFM1 phosphorylation status at Ser-116 may be an important marker for cell death involving oxeiptosis.


Product References:

Holze, C. et al. (2018) Nat Immunol. 19(2):130. (WB: human Hela, Jurkat + H2O2)


应用稀释:

ELISA    1:2000    

WB    1:1000    


规格:100 μl

MW 66 kDa


货号:AP5501

品牌:ecmbiosciences


品牌授权代理商,订购或询价:北京华泰昕生物医疗技术有限公司

电话:010-83131025

email: info@hypercyte.com

QQ: 2428 012 469